Common side effects Nausea Vomiting Diarrhea Constipation Fatigue Decreased appetite Gas/burping Abdominal cramping Less common but more serious side effects Gallbladder issues Pancreatitis Severe digestive discomfort Kidney concerns in dehydrated individuals Providers often start patients on low doses to improve tolerability
Pendulum's Akkermansia is newer, so long-term data is still accumulating
Additionally, in another Phase II study targeting patients with T2DM, orforglipron also showed significant effects in reducing A1C and weight, achieving the studys primary and secondary endpoints
Do I need a different needle to reconstitute versus inject
Tirzepatide (sold as Mounjaro and Zepbound) uses a similar step-up approach, starting at 2.5mg and increasing to 15mg maximum
The good news is you can now get generic versions of GLP-1 agonists, and your local compounding pharmacy should have access to the generic version of Ozempic, called semaglutide
